Expertise first. Treatment second. Less adding. More restoring.
A regenerative treatment that helps the skin repair and renew its own quality — delivered two ways at Hornchurch: infused through SkinPen microchannels, or injected with the Plinest® range by Mastelli.
i. The Approach
Polynucleotides are purified fragments of DNA that act as biological signals in the skin — encouraging its own cells to repair, renew and rebuild quality from within. This is a regenerative treatment, not a filler and not simply a hydrator. Skin helped to renew itself.
Best known for the delicate under-eye area, polynucleotides are a favourite of Matt’s for tired, thin or lacklustre skin. Practitioner-led throughout.
Polynucleotides can reach the skin two ways — and the right route is a consultation decision, not a menu choice.
The polynucleotide solution is delivered into the skin through the microchannels SkinPen creates — regeneration folded into the microneedling itself, with no injections. This is the treatment in the film below.
Placed precisely where the skin needs it by fine intradermal injection — three formulations for three jobs, from the delicate eye area to deeper facial remodelling. The range is below.
A closer look at the SkinPen-delivered infusion at Hornchurch — the regenerative thinking behind it.
Route One in clinic — the polynucleotide infusion, SkinPen-delivered.
For the injectable route we use the Plinest® range by Mastelli — the original Italian polynucleotide house, made with their patented PN-HPT® purification. Which formulation, and how many sessions, is decided at your consultation.
Advanced facial skin regeneration — the highest concentration of purified polynucleotides, designed to improve skin quality, texture, firmness and elasticity. A full 2ml treatment; a short course, one session every two to three weeks.
Targeted regeneration for the delicate eye area — a gentler concentration, placed with restraint. For fine lines, crepiness, elasticity and overall skin quality around the eyes. A full 2ml treatment; a short course, two to three weeks apart.
PN-HPT® polynucleotides combined with hyaluronic acid and mannitol — regeneration with an additional focus on hydration, plumpness and luminosity. A full 2ml treatment; suited to mature or dehydrated skin, and as the maintenance choice once a course is complete.
No two skins need the same formulation — your course is recommended at consultation, honestly. And where deeper resurfacing is the goal, Plinest® is also the preparation we recommend ahead of NeoGen EVO — conditioning the skin before plasma regeneration.
However they arrive — infused through microchannels or placed by needle — the biology is the same. In the skin, polynucleotides encourage the fibroblasts — the cells that make collagen and elastin — to become more active, support microcirculation, and calm inflammation. The effect is a gradual improvement in the skin’s underlying quality and resilience.
Under the eyes in particular, they help refresh thin, crepey and tired-looking skin — improving quality rather than adding volume.
Every injectable at MNP is placed personally — the same hands, the same standard, whatever the treatment.
Matt in treatment at the Hornchurch clinic.
Thin, crepey or tired under-eye skin — polynucleotides improve quality and can soften skin-quality shadowing.
Skin that’s lost quality and resilience — supported to renew itself for a firmer, healthier look.
A regenerative improvement in hydration, firmness and resilience across the face.
An honest note: under-eye dark circles have several causes. Polynucleotides help where the issue is thin or poor-quality skin — less so where it’s true hollowing or pigmentation. Matt will assess which applies to you, and tell you honestly what to expect.
The SkinPen-delivered infusion is priced at consultation. Polynucleotides are usually a short course for best results — every plan begins with an honest recommendation.
Every treatment begins with a conversation — never a rushed decision.
Book Your Consultation“Polynucleotides are one of the most exciting things I offer — genuinely regenerative, and beautiful for tired under-eye skin. As always, I’ll tell you honestly whether they’re right for your skin before we begin.”