Microspicule Matrix PHX® — The Science | Biological Microneedling

I · The Spicule

A needle, grown by nature.

Microspicules are microscopic needle-shaped structures derived from freshwater sponges, composed of natural silica or calcium salts, and measuring 200–300 micrometres — finer than a human hair.

Microneedling has moved through three generations: the mechanical dermaroller, then the automated dermapen with its controlled delivery — and now biological microneedling, where the "needle" is a natural particle massaged across the skin by hand. No device, no conventional needles: thousands of temporary micro-points of contact, created by the spicules themselves as they interact with the skin's upper layers.

1st

Dermaroller

Mechanical micropuncture of the skin — where it all began.

2nd

Dermapen

Automated, controlled microneedling with enhanced active delivery.

3rd

Biological microneedling

Microspicules: biological activation and regenerative support — no needles, no device.

Optical microscope image of bioengineered microspicules

Actual optical microscope image · bioengineered microspicules · 200–300 µm

II · The Mechanism

One particle, two actions.

Each spicule does two jobs at once — which is what separates this from both a facial and a conventional needling treatment.

01 — Contact

Controlled microstimulation

Massaged across the skin, the spicules interact with its upper layers — a controlled micro-stimulation that initiates the skin’s natural repair response: fibroblasts activate, and the synthesis of new collagen and extracellular matrix is encouraged.

02 — Delivery

A network of microchannels

Simultaneously, the spicules open a diffuse, interconnected network of temporary microchannels — carrying actives such as PDRN, Hyaluronic Acid and NAD+ past the surface, where conventional application leaves most ingredients sitting.

03 — Reservoir

A treatment with an afterlife

Spicules can remain harmlessly embedded in the skin’s upper layers for up to 72 hours before being naturally eliminated — holding the microchannels functional and the actives arriving for days after the appointment ends.

Cross-section: microspicules opening microchannels, actives reaching the dermis

Spicules at the surface · actives carried to the living layers

III · The Evidence

What the research measured.

Spicule-assisted delivery is a published, peer-reviewed field. These are the numbers reported for hydrophilic model molecules that ordinarily struggle to cross the skin.

19.4×

Hyaluronic acid

Up to 19.4× greater skin penetration than conventional topical application.

≈33×

FD-10 dextran

A fluorescent model molecule, carried roughly 33× deeper than control.

72.95×

siRNA

Large, fragile biomolecules — delivered up to 72.95× more effectively.

≈120h

Channel lifespan

The temporary microchannels remained functional for up to around 120 hours.

≈62×

Dermal accumulation

Accumulation of applied molecules measured ≈62× greater than control — the reservoir effect, quantified.

72h

Spicule retention

Partial retention in the upper layers for up to 72 hours before natural elimination.

Figures from published research on spicule-assisted transdermal delivery using model molecules — Zhang, S., Ou, H., Liu, C., Zhang, Y., Mitragotri, S., Wang, D. & Chen, M. (2017), Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules, Molecular Pharmaceutics, 14(9), 3188–3200; and Maimunah, S., Febriyanti, A. P., Fauziyah, B. & Agus, A. S. R. (2025), A Literature Review on Spicule-Assisted Transdermal Delivery Systems (S-TDS), Ad-Dawaa’ Journal of Pharmaceutical Sciences, 8(2), 137–155 — as reported in Skeyndor’s technical documentation. Laboratory measurements of delivery, not treatment outcome claims; individual results vary.

IV · The Matrix

What travels the channels matters most.

The Regenerative Activation Matrix — PDRN, Hyaluronic Acid and NAD+ — is the biological core of every treatment, chosen to support dermal regeneration, functional hydration and cellular bioenergy.

PDRN

The regenerative signal

Purified DNA and RNA fragments that support the skin’s natural repair — promoting fibroblast activity and the synthesis of collagen and other structural components of the dermal matrix. The same regenerative molecule behind our polynucleotide treatments, here delivered without a needle.

Two weights, two depths

High-molecular-weight Hyaluronic Acid forms a hydrating film at the surface, reducing water loss and strengthening barrier comfort; a very-low-molecular-weight form is drawn into the upper epidermis for plumpness, suppleness and intensive hydration.

NAD+

The bioenergy coenzyme

Nicotinamide adenine dinucleotide sits at the centre of cellular energy production, and of the skin-longevity conversation — its levels decline with age. Here it supports vitality and the skin’s ability to respond. We’ll be straight with you: topical NAD+ is a young field — the biology is compelling, and the clinical literature is still growing. We treat it as a supporting act, not the headline.

Around that core sit five targeted PRO concentrates — Lifting, Replenishing, Revitalizing, Brightening and Tone Perfecting — each built on the same PDRN and HA base and chosen for your skin at consultation: peptides and Gleditsia extract for firmness; amino acids, organic silicon and densifying lipopeptides for volume; vitamins, stabilised vitamin C and copper peptide for vitality; glutathione and Tripeptide-33 for radiance; tranexamic acid, Oligopeptide-34 and arbutin for tone.

The chemistry, signed

Spicules + NAD+

Energizing Cream PRO

Exosomes + AH-8

Lifting Complex PRO

Aminos + Pal-GQPR

Replenishing Complex PRO

Vitamins + GHK-Cu

Revitalizing Complex PRO

Glutathione + C

Brightening Complex PRO

TXA + O-34

Tone Perfecting Complex PRO

V · In Practice

Gentle by design, honest about sensation.

No needles, no device, no downtime to plan around — but this is an activation treatment, and it feels like one.

During application you’ll feel the spicules at work — a warming tingle as the cream is massaged in section by section, always adapted to you. The protocol finishes with a cooling peel-off mask to settle the skin before you leave. The spicules themselves are eliminated naturally by the skin within around 72 hours. We don’t treat over open wounds, broken skin, active eczema or severely irritated areas — and daily sun protection afterwards is essential to protect the result. Every plan starts with a consultation, so your concentrate is chosen for your skin — never defaulted.

Biological microneedling, in depth.